https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Virtual histology of cortical thickness and shared neurobiology in 6 psychiatric disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43667 Wed 28 Sep 2022 13:52:58 AEST ]]> Analyzing the role of microRNAs in schizophrenia in the context of common genetic risk variants https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29013 P < 2 × 10⁻¹⁶). Further, the gene set analyses revealed several miRNAs regulating schizophrenia risk genes, with the strongest enrichment for targets of miR-9-5p (P = .0056 for enrichment among the top 1% most-associated single-nucleotide polymorphisms, corrected for multiple testing). It is further of note that MIR9-2 is located in a genomic region showing strong evidence for association with schizophrenia (P = 7.1 × 10⁻⁸). The second and third strongest gene set signals were seen for the targets of miR-485-5p and miR-137, respectively. Conclusions and Relevance: This study provides evidence for a role of miR-9-5p in the etiology of schizophrenia. Its implication is of particular interest as the functions of this neurodevelopmental miRNA tie in with established disease biology: it has a regulatory loop with the fragile X mental retardation homologue FXR1 and regulates dopamine D₂ receptor density.]]> Wed 11 Apr 2018 15:28:50 AEST ]]> Association of Structural Magnetic Resonance Imaging Measures with Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49020 Wed 03 May 2023 12:31:22 AEST ]]> Dose-related psychotic symptoms in chronic methamphetamine users: evidence from a prospective longitudinal study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13824 Tue 24 Aug 2021 14:27:34 AEST ]]> Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21585 Tue 17 Nov 2015 14:40:08 AEDT ]]> Evaluation of Brain-Body Health in Individuals with Common Neuropsychiatric Disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51180 Thu 24 Aug 2023 14:30:56 AEST ]]> Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18570 Sat 24 Mar 2018 07:50:10 AEDT ]]> Evidence for genetic overlap between schizophrenia and age at first birth in women. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29862 2 = 1.1E-03, P = 4.1E-04), reflecting the published relationship between maternal age and SCZ risk in offspring by McGrath et al in 2014. Conclusions and Relevance: This study provides evidence for a significant overlap between genetic factors associated with risk of SCZ and genetic factors associated with AFB. It has been reported that SCZ risk associated with increased maternal age is explained by the age of the father and that de novo mutations that occur more frequently in the germline of older men are the underlying causal mechanism. This explanation may need to be revised if, as suggested herein and if replicated in future studies, there is also increased genetic risk of SCZ in older mothers.]]> Sat 24 Mar 2018 07:40:47 AEDT ]]> Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24111 Sat 24 Mar 2018 07:11:41 AEDT ]]> Association between early contact with mental health services after an offense and reoffending in individuals diagnosed with psychosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38394 Mon 29 Jan 2024 17:47:23 AEDT ]]> Neurobiological, Psychosocial, and Behavioral Mechanisms Mediating Associations Between Physical Activity and Psychiatric Symptoms in Youth in the Netherlands https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51400 Mon 04 Sep 2023 14:51:42 AEST ]]> Effectiveness of a Stand-alone Telephone-Delivered Intervention for Reducing Problem Alcohol Use: A Randomized Clinical Trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51318 Fri 27 Oct 2023 14:13:48 AEDT ]]> Association of Schizophrenia Risk with Disordered Niacin Metabolism in an Indian Genome-wide Association Study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49494 Fri 19 May 2023 10:52:01 AEST ]]> Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49142 Fri 05 May 2023 12:07:01 AEST ]]>